Are calcium ion antagonists effective anti-atherogenic agents?

The management of Brugada syndrome patients.

Brugada syndrome is a congenital electrical disorder characterised by the appearance of distinctive QRST-T patterns in the right precordial leads and an increased risk of sudden death (SCD) in young healthy adults. Although chamber enlargement is not apparent in most cases, autopsy and histological investigations have revealed structural abnormalities. The typical Brugada ECG manifestation is o...

Cardiac calmodulin kinase: a potential target for drug design.

Therapeutic strategy for cardiac arrhythmias has undergone a remarkable change during the last decades. Currently implantable cardioverter defibrillator therapy is considered to be the most effective therapeutic method to treat malignant arrhythmias. Some even argue that there is no room for antiarrhythmic drug therapy in the age of implantable cardioverter defibrillators. However, in clinical ...

Molecular basis of permeation in voltage-gated ion channels.

J on channels are pore-forming macromolecules that provide a passive conduit for ion transfer across membranes. Although simple ionophores such as gramicidin and nystatin' fall within this legalistic definition, the ion channels of eukaryotic cells are integral membrane proteins, many of which have now been isolated biochemically, reconstituted, cloned, and expressed. These fascinating proteins...

Calcium antagonists as anti-atherosclerotic agents.

Stable angina pectoris: the medical management of symptomatic myocardial ischemia.

Coronary artery disease (CAD) remains an important cause of morbidity and mortality and is a serious public health problem. Over the last 4 decades there have been dramatic advances in the both the prevention and treatment of CAD. The management of CAD was revolutionized by the development of effective surgical and percutaneous revascularization techniques. In this review we discuss the importa...